Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex
Abstract O-GlcNAcylation is a conserved post-translational modification that attaches N-acetyl glucosamine (GlcNAc) to myriad cellular proteins.In response to nutritional and hormonal signals, O-GlcNAcylation regulates diverse cellular processes by modulating the stability, structure, and function of target proteins.Dysregulation of O-GlcNAcylation